• Latest
  • Trending

$126M NIH grant to help map the brain, study diseases like Alzheimer's – Medical News Today

October 16, 2022
OccupyBoGProtest: Police to Enforce Restricted Access to Bank of Ghana

OccupyBoGProtest: Police to Enforce Restricted Access to Bank of Ghana

October 4, 2023
#OccupyBoGProtest: Tense Confrontation Erupts Between Police and Demonstrators

#OccupyBoGProtest: Tense Confrontation Erupts Between Police and Demonstrators

October 4, 2023
ADVERTISEMENT

President Akufo-Addo Expresses His Condolence to the Lives Lost at Bogoso-Apiatse

October 3, 2023

Ghana Honors Late Former First Lady Theresa Kufuor with Flags at Half-Mast

October 3, 2023
The Rise of E-Sports: How Video Gaming Became a Billion-Dollar Industry

The Rise of E-Sports: How Video Gaming Became a Billion-Dollar Industry

October 3, 2023
Remembering E.T. Mensah: A Statesman’s Journey Through Ghana’s Political Landscape

Remembering E.T. Mensah: A Statesman’s Journey Through Ghana’s Political Landscape

October 3, 2023
black and silver solar panels

Breakthrough in Renewable Energy: Solar-Powered Nanomaterial Promises a Sustainable Future

October 2, 2023

The History of Football

October 2, 2023
people gathering on street holding ukraine flags

The Russia-Ukraine Conflict: A Prolonged Crisis with Global Implications

October 1, 2023
people carrying flags while marching for peace

Diplomatic Efforts in the Russia-Ukraine Conflict

October 1, 2023
ADVERTISEMENT
  • Fixtures & Standings
  • Livescore
  • Religion
  • Online Radio
  • Contact Us
  • About Us
  • Privacy Policy
Wednesday, October 4, 2023
FacetvNews
No Result
View All Result
  • Login
  • News
  • Politics
    • Government
  • Ghana
  • Africa
  • Middle East
  • World
  • Entertainment
    • Music Videos
    • Celebrity
    • Videos
  • security
    • Military
    • Russia-Ukraine Crises
  • nigeria
  • Religion
  • sports
    • International Sports
    • Ghana Sports
    • Ghana football
    • World Football
  • History
    • Education
  • social
    • Economy
  • News
  • Politics
    • Government
  • Ghana
  • Africa
  • Middle East
  • World
  • Entertainment
    • Music Videos
    • Celebrity
    • Videos
  • security
    • Military
    • Russia-Ukraine Crises
  • nigeria
  • Religion
  • sports
    • International Sports
    • Ghana Sports
    • Ghana football
    • World Football
  • History
    • Education
  • social
    • Economy
No Result
View All Result
Morning News
No Result
View All Result
ADVERTISEMENT
Home Featured featured

$126M NIH grant to help map the brain, study diseases like Alzheimer's – Medical News Today

Facetvnews by Facetvnews
October 16, 2022
in featured
0 0
0
0
SHARES
0
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

For such an important organ in the body, there is still quite a lot we do not know about the human brain. While we may understand what different areas of the brain do, much is still unknown about how the 86 billion neurons in the brain communicate with each other. And researchers are still working to uncover how the brain changes through neurological disorders.
Now researchers at the Salk Institute in La Jolla, CA, are hoping to increase our knowledge of the brain through the launching of the Center for Multiomic Human Brain Cell Atlas.
Center researchers plan to better understand how all the individual cells in the brain work and how they change as the body ages. They also hope to use their work to create potential therapies for brain-related diseases.
The new Center for Multiomic Human Brain Cell Atlas is reportedly part of the BRAIN Initiative at the National Institutes of Health (NIH). It is funded through a five-year, $126 million grant from the NIH.
The Center’s work builds upon a five-year project called the BRAIN Initiative Cell Census Network aimed at mapping all the cells in a mouse brain and how they work together.
“Similar to the way we learned about space travel from short trips to the moon, the mouse brain mapping project taught us a lot about how to approach a much bigger brain and the types of genomic information we would need to be able to truly map the human brain,” explains Dr. Joseph Ecker, director of the Genomic Analysis Laboratory at the Salk Institute, a Howard Hughes Medical Institute investigator, and leader of the new Center.
“This project is an example of how fruitful teamwork can be in science — these types of projects cannot be accomplished in a single lab,” Dr. Ecker said.
Center researchers will study 1,500 brain samples from 50 regions of 30 human brains of various ages. From every cell in each brain region, scientists plan to isolate each nucleus — the part of the cell containing the cell’s genetic material. Researchers will also record each cell’s molecular details, including its chromatin architecture — the 3D structure of the cell’s chromosomes — and DNA methylation, or how the cell’s DNA acts when a specific chemical tag is added to it.
Medical News Today spoke with Dr. David W. Dodick, emeritus professor, distinguished investigator, and distinguished educator at the Mayo Clinic, chair of the American Brain Foundation, and co-chair of the Atria Academy of Science and Medicine, about the new research project.
“This collaborative interdisciplinary research will use some of the most advanced methods to identify the molecular signature of each brain cell and promises to unlock the secrets of how the brain ages, as well as how alterations over time in the genetic material and the proteins produced lead to different brain diseases,” said Dr. Dodick. “This knowledge could facilitate the development of strategies and treatments that prevent, treat, and cure brain diseases.”
For its research, the Center will reportedly focus mainly on epigenetics. Epigenetics, which means “in addition to changes in genetic sequence,” studies any process that changes gene activity without physically altering DNA.
As discussed above, DNA methylation is an example of an epigenetic change. Epigenetic changes occur throughout a person’s lifetime due to certain environmental changes or behaviors, such as physical activity and diet. Your genes can also change due to aging and certain diseases like cancer and infections.
“Essentially, we want to take millions, even hundreds of millions of brain cells, learn everything we can about their epigenetics and how their chromatin is arranged, and project them in a spatial context so we can see where these cells live and understand how all of the cells in any brain region are organized, and at any age,” Ecker said. “At the moment, we have almost no data like that for the human brain.”
According to Dr. Santosh Kesari, a neurologist at Providence Saint John’s Health Center in Santa Monica, CA, and regional medical director for the Research Clinical Institute of Providence Southern California, studying epigenetics provides a broader way of looking gene expression — the process where our genes turn “on” to produce RNA and cellular proteins or turn “off” to serve a different function.
“It’s a more complex analysis because it gives us a global view,” he explained to MNT. “It tells you what genes are turned on, what genes are turned off, and at what level. And then we can use that to figure out what genes may be associated with diseases. And really immediately gives us ideas about how to maybe affect the disease by modulating particular genes.”
By having a better understanding of how all the cells in the brain work, Center researchers plan to use that information to establish a baseline scientists can use to compare brains with neurological and psychological disorders, including Alzheimer’s disease, autism, depression, and traumatic brain injury.
“The brain map we develop could help point disease researchers in the right direction — for example, we could say ‘That’s the region of the genome, in that specific subset of neurons, in that part of the brain, where a molecular event goes awry to cause that disease,’” Ecker details. “And ultimately this information might help us design gene therapies that target only the cell populations where the treatment is needed — delivering the right genes to the right place at the right time.”
“We’ve understood the disorders to some extent with imaging and doing bulk analysis of brains or areas of the brain, but I think we’re just going to learn even more,” Dr. Kesari added. “The reality is there are many different types of cells in the brain. In the area of injury or in the area of Alzheimer’s plaque, what happens in that microenvironment and how (do) those cells contribute to causing disease is unknown. But now (if) you can study every single cell, so you may get insights that are very unexpected and lead to better treatment options and ideas.”
Researchers have found that metabolites from certain diets may be linked to better—or worse—cognitive function across different races and ethnicities.
A new study has found a correlation between having a higher body mass index and waist circumference later in life, and a faster rate of brain aging.
Researchers discovered a microprotein called SHMOOSE, which appears to have a physiological role in neurodegeneration, and its mutation is linked to

A new study has found that walking almost 10,000 steps a day may reduce a person's dementia risk by around 50%. However, even those who walk less may

Researchers identified seven lifestyle habits, such as regular physical activity and social contact, that can help reduce dementia risk for people

OUR BRANDS

source

READ ALSO

Existing heart medication may help treat alcohol use disorder – Medical News Today

Why Is Ghana Turning to the IMF? – Foreign Policy

Tags: @facetvnews

Related Posts

featured

Existing heart medication may help treat alcohol use disorder – Medical News Today

October 21, 2022
featured

Why Is Ghana Turning to the IMF? – Foreign Policy

October 21, 2022
featured

Bill Squadron featured in ABC News report on transparency of NIL deals – Today at Elon

October 21, 2022
featured

Warning signs posted after box jellyfish spotted in Waikiki – Hawaii News Now

October 21, 2022
featured

No tax hikes, fee increases in Barlow's $55 million budget for 2023 – oswegocountynewsnow.com

October 21, 2022
featured

Steven Gerrard out as manager of Aston Villa – Lethbridge News Now

September 30, 2023
Next Post

Neymar faces fraud trial for Barcelona transfer from Santos - Lethbridge News Now

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

POPULAR NEWS

Close-up image of An old book with music notes. Sheet music with notes and lyrics

Lyrics: Sarkodie – Goodbye

February 8, 2022

Sanibel transmission line expected be energized today | News, Sports, Jobs – Sanibel-Captiva Islander

September 30, 2023

The Weather Today

October 1, 2023

Public urged to visit PURC for redress of utility challenges – News Ghana

October 16, 2022

John Legend Announces In-Store Album Signing Events for ‘LEGEND’

September 5, 2022

EDITOR'S PICK

Government to increase SHS transition rate to university – Minister – Ghana Business News

November 4, 2022

Ghana teachers reject change from three term academic calendar to semester system – BBC

November 2, 2022

League One team of the week dominated by Oxford United and Bolton Wanderers as Barnsley man features – The Yorkshire Post

November 17, 2022
Police-meets-with-National-Courier-Association-Ghana

Give Your Members IDs – IGP To Courier Service Operators

December 7, 2021
ADVERTISEMENT

About

We bring you the best Premium WordPress Themes that perfect for news, magazine, personal blog, etc. Check our landing page for details.

Follow us

Categories

Recent Posts

  • OccupyBoGProtest: Police to Enforce Restricted Access to Bank of Ghana
  • Fixtures & Standings
  • Livescore
  • Online Radio
  • Religion
  • Contact Us

© 2021 FacetvNews -All Rights Reserved - Powered by McPerry imaginations.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • Politics
  • National
  • Business
  • World
  • Entertainment
  • Health
  • Lifestyle
  • Opinion
  • Science
  • Tech
  • Stories
  • History

© 2021 FacetvNews -All Rights Reserved - Powered by McPerry imaginations.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Are you sure want to unlock this post?
Unlock left : 0
Are you sure want to cancel subscription?