Play Now <br> <a href="/fantasy/games/football/office-pool-manager/" class="">Football Pick'em</a> <br> Play Now <br> <a href="https://picks.cbssports.com/college-football/pickem" class="">College Football Pick'em</a> <br> <a href="/podcasts/fantasy-football-today-podcast/" class="">Start or Sit</a> <br> <a href="/podcasts/nothing-personal-with-david-samson/" class="">Talking the business of sports</a> <br>The 2-1 <a class="Annotation-link" href="https://www.cbssports.com/college-football/teams/ARIZ/arizona-wildcats/">Arizona Wildcats</a> head to the Bay Area to face the only team they defeated in 2021, the 2-1 <a class="Annotation-link" href="https://www.cbssports.com/college-football/teams/CAL/california-golden-bears/">California Golden Bears</a> on Saturday afternoon at FTX Field at California Memorial Stadium in Berkeley, CA. The Wildcats enter after defeating <a class="Annotation-link" href="https://www.cbssports.com/college-football/teams/NDST/north-dakota-state-bison/">North Dakota State</a> 31-28 last Saturday night. They are 1-0 on the road this season with a convincing win over <a class="Annotation-link" href="https://www.cbssports.com/college-football/teams/SDGST/san-diego-state-aztecs/">San Diego State</a> in Week 1. Cal is 2-0 at home but coming off a tight 24-17 loss to <a class="Annotation-link" href="https://www.cbssports.com/college-football/teams/ND/notre-dame-fighting-irish/">Notre Dame</a> on the road.<br>Kickoff is set for 5:30 p.m. ET. The Golden Bears are favored by 3 points in the latest California vs. Arizona odds from Caesars Sportsbook, and the over/under is set at 50. Before entering any Arizona vs. California picks, <a href="https://www.sportsline.com/insiders/california-vs-arizona-odds-line-spread-proven-model-reveals-college-football-picks-predictions-for-week-4-2022/#ttag=09212022_agg_cbssports_picks_football_ncaa_model_AZCALcfbauto" target="_blank" rel="noopener">you'll want to see the college football predictions from the model at SportsLine</a>.<br>The SportsLine Projection Model simulates every FBS <a href="/college-football/" data-is-autolink="true">college football</a> game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.<br>Now, the model has set its sights on <a href="https://www.sportsline.com/college-football/game-forecast/NCAAF_20220924_ARIZ@CAL/" target="_blank" rel="noopener">California vs. Arizona</a>, and just locked in its picks and CFB predictions. <a href="https://www.sportsline.com/insiders/california-vs-arizona-odds-line-spread-proven-model-reveals-college-football-picks-predictions-for-week-4-2022/#ttag=09212022_agg_cbssports_picks_football_ncaa_model_AZCALcfbauto" target="_blank" rel="noopener">You can head to SportsLine to see its picks</a>. Here are several <a href="https://www.sportsline.com/ncaaf/odds"> college football odds</a> and betting lines for California vs. Arizona:<br>Arizona defeated FCS powerhouse North Dakota State 31-28 last Saturday to complete a successful 2-1 non-conference season. Transfer QB <a class="Annotation-link" href="/college-football/players/3176945/jayden-de-laura/">Jayden de Laura</a> was efficient, completing 20 of 28 passes for 229 yards and a touchdown in the victory. He also added 50 yards and a score on 10 rushing attempts. Arizona boasts a strong receiving unit led by <a class="Annotation-link" href="https://www.cbssports.com/college-football/teams/UTEP/utep-miners/">UTEP</a> transfer <a class="Annotation-link" href="/college-football/players/3133200/jacob-cowing/">Jacob Cowing</a>, 5-star true freshman <a class="Annotation-link" href="/college-football/players/28877124/tetairoa-mcmillan/">Tetairoa McMillan</a>, and <a class="Annotation-link" href="/college-football/players/26730616/dorian-singer/">Dorian Singer</a>. Cowing has 21 catches for 253 yards and five touchdowns in his three games as a Wildcat.<br>Arizona added two more rushing scores against the Bison from <a class="Annotation-link" href="/college-football/players/3128079/michael-wiley/">Michael Wiley</a> and <a class="Annotation-link" href="/college-football/players/28877250/jonah-coleman/">Jonah Coleman</a>, both players who averaged more than five yards per rushing attempt in the game. Last year, Arizona defeated the Golden Bears 10-3 for the team's only win of the 2021 season. Cal was down 24 players due to health protocols and in an ugly offensive game, the Wildcats took advantage. <br>The Golden Bears blew a 17-14 lead at the end of the third quarter, giving up 10 unanswered points to Notre Dame in last week's close road defeat. QB <a class="Annotation-link" href="/college-football/players/2961162/jack-plummer/">Jack Plummer</a>, a transfer from <a class="Annotation-link" href="https://www.cbssports.com/college-football/teams/PURDUE/purdue-boilermakers/">Purdue</a>, struggled with his accuracy, going 16 of 37 for 184 yards, one touchdown and no interceptions in the loss. Despite the offensive challenges, Cal nearly outgained the Fighting Irish, only being short by one yard, 297-296.<br>Junior wide receiver <a class="Annotation-link" href="/college-football/players/3176975/jeremiah-hunter/">Jeremiah Hunter</a> leads the team with 223 yards on 16 receptions and J. Michael Sturdivant has 14-165-1, with the score coming last week against Notre Dame. The Golden Bears might have a challenge through the air against Arizona, who ranks among the top-20 in passing yards allowed. The Wildcats are in the bottom 25 in terms of rushing yards against per game so there's a big opportunity for Cal's ground game led by <a class="Annotation-link" href="/college-football/players/28876778/jaydn-ott/">Jaydn Ott</a> to have success.<br>The model has simulated California vs. Arizona 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in almost 70% of simulations. <a href="https://www.sportsline.com/insiders/california-vs-arizona-odds-line-spread-proven-model-reveals-college-football-picks-predictions-for-week-4-2022/#ttag=09212022_agg_cbssports_picks_football_ncaa_model_AZCALcfbauto" target="_blank" rel="noopener">You can only see the pick at SportsLine</a>.<br><strong>So who wins the matchup between Arizona and California? And which side of the spread hits almost 70% of the time? <a href="https://www.sportsline.com/insiders/california-vs-arizona-odds-line-spread-proven-model-reveals-college-football-picks-predictions-for-week-4-2022/#ttag=09212022_agg_cbssports_picks_football_ncaa_model_AZCALcfbauto">Visit SportsLine now to see which side of the Arizona vs. California spread to jump on, all from the advanced model that finished the past six-plus years up more than $3,300 on its FBS college football picks</a>, and find out.</strong><br>© 2004-2022 CBS Interactive. All Rights Reserved.<br>CBS Sports is a registered trademark of CBS Broadcasting Inc. Commissioner.com is a registered trademark of CBS Interactive Inc.<br>Images by Getty Images and US Presswire<br><br><a href="https://www.cbssports.com/college-football/news/california-vs-arizona-prediction-odds-line-2022-college-football-picks-week-4-best-bets-from-proven-model/">source</a>
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